Her de engelske referencer til en række spændende studier af forskellig art og emner.
HYDROGEN LARGE REVIEW STUDY SPANNING MULTIPLE FIELDS, RELATING TO VARIOUS APPLICATIONS OF HYDROGEN.
“Molecular hydrogen: a preventive and therapeutic medical gas for various diseases”
By Li Ge, Ming Yang et al. for:
Department of Histology and Embryology, School of Basic Medical Sciences, Taishan Medical University, Tai-an City, Shandong Province, China.
Department of Clinical Medicine, Taishan Medical University, Tai-an City, Shandong Province, China.
Key Laboratory of Atherosclerosis in Universities of Shandong, Taishan Medical University, Institute of Atherosclerosis, Taishan Medical University, Tai-an City, Shandong Province, China.
Department of medical immunology, School of Basic Medical Sciences, Taishan Medical University, Tai-an City, Shandong Province, China.nff
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HYDROGEN WATER STUDIES ON SPORTS PERFORMANCE ENHANCEMENT
“Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study”.
Canadian Journal of Physiology and Pharmacology, 2019 Sep;97(9):857-862.
By: Toshio Mikami et al.
Endurance and fatigue were significantly improved in the H2 group as judged by maximal oxygen consumption and Borg’s scale, respectively. Taken together, drinking H2 water just before exercise exhibited anti-fatigue and endurance effects.
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“Molecular Hydrogen in Sports Medicine: New Therapeutic Perspectives”.
Int J Sports Med, 2014. (human) by: S.M Ostojic.
Review focusing on the applications of hydrogen in sports injury and sports performance enhancement.
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“Adequate hydration with hydrogen-rich water pre-exercise, reduced blood lactate levels and improved exercise-induced decline of muscle function.”
Aoki, K., et al.
Pilot study: “Effects of drinking hydrogen-rich water (is hydrogen water with an above average dissolved hydrogen content) on muscle fatigue caused by acute exercise in elite athletes.” Although acute exercise resulted in an increase in blood lactate levels in the subjects given regular water, oral intake of hydrogen rich water prevented an elevation of blood lactate during heavy exercise. Peak torque of subjects on regular water significantly decreased during maximal isokinetic knee extension, suggesting muscle fatigue, but peak torque of subjects on hydrogen rich water didn’t decrease at early phase.
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“Drinks with alkaline negative oxidative reduction potential (H2) improve exercise performance in physically active men and women: double-blind, randomised, placebo-controlled, cross-over trial of efficacy and safety”. Ostojić, S.M., et al.
Serbian journal of sports sciences, 2011. 5(1-4): p. 83-89.
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“Molecular Hydrogen Affected Post-Exercise Recovery in Judo Athletes.”
Post-exercise lactate levels blunted in hydrogen rich water group vs. placebo.
The sports performance enhancement in a study like this is indirect, potentially leading to increased restitution and recovery times after exercise.
Drid, Patrik et al.
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HYDROGEN GAS AND WATER RELATING TO WEIGHT LOSS AND METABOLISM
Molecular hydrogen improves obesity and diabetes…and stimulating energy metabolism in mice
Naomi Kamimura et al.
Recent extensive studies have revealed that molecular hydrogen H2 has great potential for improving oxidative stress-related diseases by inhaling H2 gas, injecting saline with dissolved H2, or drinking hydrogen rich water; however, little is known about the dynamic movement of H2 in a body.
First, we show that liver glycogen accumulates H2 after oral administration of Hydrogen-rich water, explaining why consumption of even a small amount of hydrogen over a short span time efficiently improves various disease models.
The benefits of drinking hydrogen water ad libitum, on type 2 diabetes was investigated, using db/db obesity mice. Drinking Hydrogen water reduced oxidative stress in the liver, and significantly alleviated fatty liver in db/db mice as well as high fat-diet-induced fatty liver in wild-type mice.
Long-term drinking of hydrogen rich water significantly controlled fat and body weights…
Drinking Hydrogen water also decreased levels of plasma glucose, insulin, and triglyceride, the effect of which on hyperglycemia was similar to diet restriction!!!.
To examine how drinking Hydrogen rich water improves obesity and metabolic parameters at the molecular level, gene-expression profiles were examined.
The findings were that, indeed, hydrogen (H2) stimulated energy metabolism as measured by oxygen consumption. The present results suggest the potential benefit of Hydrogen (H2) in improving obesity, diabetes, and metabolic syndrome.
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HYDROGEN WATER BENEFITS
IN ANTI-AGING, SKIN HEALTH, BEAUTY AND WOUND HEALING
Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro.
Li, Q., et al.
Twenty-two patients were retrospectively divided into an effective group (EG, n = 12) and a less effective group (LG, n = 10) according to the outcomes of endpoint evaluation and the healing criteria. PU hospitalized days in EG were significantly shorter than in LG (113.3 days vs. 155.4 days, p < 0.05), and the shortening rate was approximately 28.1%. Either in EG or in LG, the reducing changes (EG: 91.4%; LG: 48.6%) of wound size represented statistically significant difference versus before Hydrogen Water intake (p < 0.05, p < 0.001). The in vitro data demonstrate that intracellular ROS (Free radicals) as quantified by NBT assay was diminished by Hydrogen Water, but not by Regular Water.
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“Hydrogen(H2) treatment for acute erythematous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers”.
Ono, H., et al.
Erythema of these 4 patients and associated symptoms improved significantly after the Hydrogen treatment and did not recur. Administration of H2 did not change physiological parameters and did not cause deterioration of the blood chemistry.
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The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae Allergen in NC/Nga Mice.
Drinking hydrogen water suppressed the levels of inflammation-related mediators such as Th1, Th2, and pro-inflammatory cytokines which are number one players in the pathogenesis of human Atopic Dermatitis. In addition, this study provides a new insight of the relevance of certain cytokines in AD. Hydrogen Water represents a potentially alternative therapeutic and preventive treatment of Atopic Dermatitis.
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“Hydrogen-rich Electrolyzed Warm Water Represses Wrinkle Formation Against UVA Ray Together With type-I Collagen Production and Oxidative-Stress Diminishment in Fibroblasts and Cell-Injury Prevention in Keratinocytes”
KATO, S., et al. (2012).
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Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
Cosmotology Clinic ”Beauty Institute”. Moscow, conclusion No.127 from 23.04.2003, No173 of 09.07.2003.
OHSAWA, I., ISHIKAWA, M., et al. (2007). Nat Med 13, 688-694.
Hydrogen enriched water improved mitochondria dysfunction.
Ito, M., et al.
Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies.
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HYDROGEN WATER
PROTECTION AGAINST FREE RADICALS (ROS)
CAUSED BY TOXINS, HEAVY METALS AND RADIATION
Molecular hydrogen and radiation protection.
Chuai, Y., et al. Free Radical Research, 2012. 46(9): p. 1061-7.
Molecular hydrogen (hydrogen water) acts as a therapeutic antioxidant by selectively reducing hydroxyl radicals (•OH) and peroxynitrite (ONOO-). It has been well-known that ionising radiation (IR) causes oxidative damage and consequent apoptosis (cell-death) mainly due to the production of •OH that follows radiolysis of H(2)O. Our department reported the protective effect of H(2) in irradiated cells and mice for the first time, and this effect is well repeated by us and another laboratory in different experimental animal models.
Comment: This may show to be a relevant study in other radiation models, such as in strong radiation fields generated by microwave or mobile radiation in the 5 GHz range, as currently debated internationally.
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HYDROGEN WATER & HYDROGEN GAS
“Hydrogen Gas in Cancer Treatment”.
Sai Li et al.
“…Growing evidence has shown that hydrogen gas can either alleviate the side effects caused by conventional chemotherapeutics, or suppress the growth of cancer cells and xenograft tumor, suggesting its broad potent application in clinical therapy. In the current review, we summarize these studies and discuss the underlying mechanisms.”
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“Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors”.
Kang, K.-M., et al.
The consumption of hydrogen-rich water for 6 weeks reduced reactive oxygen metabolites in the blood and maintained blood oxidation potential. The Quality of Life (QOL) scores during radiotherapy were significantly improved in patients treated with hydrogen-rich water compared to patients receiving placebo water.
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“Hyperbaric hydrogen therapy: a possible treatment for cancer”.
Dole, M., F.R. Wilson, and W.P. Fife. Science, 1975. 190(4210): p. 152-4.
“Mice with squamous cell carcinoma were exposed to a mixture of oxygen and hydrogen at a total pressure of 8 atmospheres for periods up to 2 weeks in order to see if a free radical decay catalyzer, such as hydrogen, would cause a regression of the skin tumors. Marked aggression of the tumors was found, leading to the possibility that hyperbaric hydrogen therapy might also prove to be of significance in the treatment of other types of cancer”.
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Matsushita, T., et al. Jpn J Radiol, 2011. 29(7): p. 503-12.
Investigation of protective effect of hydrogen-rich water against chemotherapy-induced (cisplatin) nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging.
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